[SEP monitoring during clonidine therapy of alcohol delirium].

M Lorenz, L Verner, M Hartmann, M R Gaab
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引用次数: 0

Abstract

In 12 patients with developing alcohol withdrawal syndrome after abdomino-thoracic surgical procedures who were treated with Clonidine, short latency somatosensory evoked potentials were recorded. Clonidine leads to a good sedation, anxiolysis and moderated the psychotic symptoms. However, there was no significant correlation between the Clonidine medication and the SEP results over the time of drug administration concerning the primary cortical response N20 and the following N20/P25 wave. Therefore, the short-latency SEP-recording cannot provide a reliable monitoring of the good sedative effect of Clonidine in alcoholic withdrawal. The SEP responses after Clonidine are like those of morphine and are thought to have a similar central mode of action.

[可乐定治疗酒精性谵妄时SEP监测]。
在12例胸腹外科手术后出现酒精戒断综合征的患者中,用可乐定治疗,记录了短潜伏期体感觉诱发电位。可乐定具有良好的镇静、抗焦虑和缓解精神病症状的作用。然而,在原发皮质反应N20和随后的N20/P25波方面,可乐定用药与SEP结果随给药时间的变化无显著相关性。因此,短潜伏期sep记录不能可靠地监测可乐定在酒精戒断中的良好镇静作用。可乐定后的SEP反应与吗啡相似,被认为具有类似的中枢作用模式。
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