Simulation of cell to cell interaction during reentrant activation

V. Kowtha, J.K. Li
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Abstract

The cardiac electrophysiological phenomena of reentrant excitation has been postulated as a possible mechanism for ventricular arrhythmias. Reentrant activation has been shown with the surviving epicardial layer as the electrophysiological substrate in a four-day canine post left anterior descending artery occlusion model. The thin surviving epicardial layer was simulated by a two-dimensional finite cable model with the active membrane properties modeled by modified Beeler-Reuter kinetics. The model surface consists of the periphery-reflecting normal membrane properties with progressively depressed membrane properties and decreased cellular coupling at the center of the surface. The functional significance of the simulation study of cell-cell electrical interaction during reentrant excitation is to provide a basis for understanding the spatial gradations of conduction velocity observed as regions of slow conduction leading to functional conduction block in the reentrant circuit.<>
重入激活过程中细胞间相互作用的模拟
重入性兴奋的心脏电生理现象已被假定为室性心律失常的可能机制。在犬左前降支闭塞后4天的模型中,以幸存的心外膜层作为电生理基质显示了可重入激活。心外膜存活层采用二维有限索模型模拟,活性膜特性采用改进的Beeler-Reuter动力学模型模拟。模型表面由外周反射的正常膜性质组成,膜性质逐渐降低,表面中心的细胞耦合减少。重入激励过程中细胞-细胞电相互作用的模拟研究的功能意义在于为理解在重入回路中作为导致功能性传导阻滞的慢传导区域所观察到的传导速度的空间梯度提供了基础。
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