Adjuvantas in construction of mixed vaccines against infectious enterites of calves

Abstract

Introduction. an etiology of gastrointestinal tract diseases of calves the main role is played by viruses of infectious rhinotracheitis, diarrhea, rotavirus and coronavirus infection, escherichiosis and salmonellosis. The main method of their control of of adjuvants to increase their immunogenicity. A number of adjuvants – mineral (an aluminum hydroxide, potassium alum), oil (an incomplete Freund's adjuvant, эмульсиген, montanida, Marcala), natural polysaccharides is known (bacterial lipopolysaccharides, the activated cellulose) are known. In this regard selection of optimum adjuvant when designing vaccines is a current problem in biotechnology. vaccines against infectious gastroenteritis of calves, was established that all adjuvants had a positive impact on biosynthesis of specific antibodies. At the same time a vaccinated animals antiserum capacity increased by 4-7 log 2 . Conclusions and prospects of further researches. When choosing optimum adjuvant in the designed vaccines against gastroenteritis of an infectious etiology of calves, more pronounced stimulation of a humoral immune response were received when using oil IZA-15 and IZA-25 adjuvant.