Antipsychotic Polypharmacy and High Doses in a Rural Portuguese Community Mental Health Service

Sara Ramos, D. Cruz, B. Jesus, J. Correia, Isabel Vaz, J. Mendes
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引用次数: 2

Abstract

Introduction: Antipsychotic polypharmacy (APP) and high dose (APHD) remain a common practice in the treatment of severe mental illness, even though they are not supported by current international guidelines. Methods: We aimed to establish the prescribing patterns of antipsychotics in a community mental health service in a rural setting, to determine the prevalence of APP and APHD treatment and to identify associated factors. Results: We identified 284 patients. APP was present in 46.5% patients and was associated to younger age, single status, more previous psychiatric admissions, and anticholinergic prescription. Prescription of APHD was observed in 14.4% patients and was associated with previous inpatient admissions, being prescribed with a first generation long‑acting injectable antipsychotic and anticholinergics. We also found that APP and APHD were mutually associated. Conclusion: Despite current guidelines, we found prevalences of APP and APHD of 46.5% and 14.4%, respectively. Further studies are necessary to better evaluate the antipsychotic prescription patterns in Portugal.
葡萄牙农村社区精神卫生服务的多重抗精神病药物和高剂量
多药抗精神病药物(APP)和高剂量抗精神病药物(APHD)仍然是治疗严重精神疾病的常见做法,尽管目前的国际指南不支持它们。方法:我们旨在建立农村社区精神卫生服务机构抗精神病药物的处方模式,以确定APP和APHD治疗的患病率,并确定相关因素。结果:我们发现284例患者。46.5%的患者存在APP,与年龄较小、单身、既往精神科就诊较多和抗胆碱能药物处方有关。14.4%的患者有APHD的处方,并且与以前的住院患者有关,被开了第一代长效注射抗精神病药和抗胆碱能药。我们还发现APP和APHD是相互关联的。结论:尽管有现行的指南,我们发现APP和APHD的患病率分别为46.5%和14.4%。需要进一步的研究来更好地评估葡萄牙的抗精神病药物处方模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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