Effects of vitamin E, methylprednisolone and nedocromil sodium on healing of rats with experimentally created intraabdominal adhesions

Abstract

of rats weighing 280 to 330 g were divided into four equal groups. 5 ml of 0.9% NaCl was given to the control group, 5 ml of methylprednisolone was given to group 2, 5 ml of vitamin E to group 3 and 5 ml of nedocromil sodium to group 4 were given intraabdominally. On the 14 th postoperative day, all rats were sacrificed and re-laparotomy was performed. Intraabdominal adhesions were scored according to the Nair classification. Results: When the groups were compared dyadically, the difference between group 1 and group 2 was found to be statistically significant ( p = 0.011). The difference between group 1 and group 3 was statistically significant ( p = 0.011). The difference between group and group 4 ( p = 0.007). There was no statistically significant difference between group 2 and group 3, and group 2 and group 4, and group 3 and group 4 ( p < 0.05). Conclusions: As a result, methylprednisolone, vitamin E and nedocromil sodium have been shown to have a healing effect on adhesions.