Evaluation of the in-vitro antifungal activity of Holoptelea Integrifolia ethanolic extract loaded in microemulsion

Priyanka Chaturvedi, P. Sharma
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Abstract

Microemulsions improve the transdermal delivery of several drugs over conventional topical preparations such as emulsions and gels: enhanced drug solubilization, increased skin flux, and decreased diffusion coefficient. Microemulsion-based systems find significant improvement in the topical delivery of antifungals. We believe that drug-loaded microemulsion will show better antifungal activity by better penetration into the skin and fungal cells. Antifungal agents are mostly lipophilic and easily formulated in topical vehicles. Microemulsions were prepared by the phase titration method. Formulations of the same drug and Excipient ratio and different concentrations were optimized with selected parameters like pseudo ternary phase diagram, particle analysis size, zeta potential validation, entrapment efficiency, and drug release studies performed by dialysis bag diffusion techniques at a temperature (37ºC). The study continued for 24 hours. The maximum amount of drug Holoptelea integrifolia release is 90% within 8hr. The study was monitored at 37ºC. Successfully done preparation, characterization, and drug release study of Microemulsion drug loaded.
微乳荷叶全息乙醇提取物体外抑菌活性评价
与乳液和凝胶等常规外用制剂相比,微乳液改善了几种药物的透皮递送:增强了药物的增溶性,增加了皮肤通量,降低了扩散系数。微乳化系统在局部递送抗真菌药物方面有显著改善。我们认为,载药微乳可以更好地渗透到皮肤和真菌细胞中,从而显示出更好的抗真菌活性。抗真菌药物大多是亲脂性的,很容易在局部车辆中配制。采用相滴定法制备微乳。选取拟三元相图、颗粒分析尺寸、zeta电位验证、包封效率以及透析袋扩散技术在37℃温度下的药物释放研究等参数,对相同药物和辅料配比、不同浓度的处方进行优化。研究持续了24小时。8小时内药物最大释放量为90%。研究在37℃进行监测。成功完成了微乳载药的制备、表征及释药研究。
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