Microelectronic circuits analogous to hydrogen bonding networks in Michaelis complex of beta-lactamase protein

Abstract

A microelectronic circuit of block-elements functionally analogous to two hydrogen bonding networks is investigated in the present paper. The hydrogen bonding networks are extracted from Michaelis complex of β-lactamase protein. They are described by electrical circuits. The hydrogen bonds of the networks are presented by three- or four-terminal block-elements in the juxtaposed electrical circuits. The block-elements are coded in Matlab with polynomials and static and dynamic analyses are performed. The circuits' behavior appeared to be similar to current source or amplifier, and signal modulator.