Optical detection in Biochips: A fuzzy based detection analyzer for homogeneous samples in DMFBs

Abstract

In this work, we propose an architecture for optical detection based analyzer to be integrated with Digital Microfluidic Biochips (DMFB). A reference memory has been integrated with the device to define pre-characterized data for the multiple reference levels. The architecture has been developed towards the implementation of the fuzzy based control of the process flow for extending the analysis to multiple levels and determination of the extent of infestation of the targeted parameters for a set of homogeneous samples subjected to specified Bioassay protocol. The design is implemented on FPGA platform using Xilinx Spartan 3E for the detection of the blood glucose on a group of homogeneous samples. The simulation results are found to be satisfactory and the detection results are found to be in conformance with the conventional benchtop laboratory procedures.