Mitochondrial Pyruvate Carrier 1 and 2 Heterodimer, In Silico, Models of Plant and Human Complexes: A Comparison of Structure and Transporter Binding Properties

Int. J. Knowl. Discov. Bioinform. Pub Date : 2017-07-01 DOI:10.4018/IJKDB.2017070102

Jason L. Dugan, Allen K. Bourdon, C. Phelix

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引用次数: 5

Abstract

Theplantandhumanmitochondrialpyruvatecarrier(MPC)hadbeenstudiedinthe1970s-1990s providingmanypredictionsonfunctionalproteinstructureandmechanismsofsubstratebinding.Genes forhumanandplantMPChavebeenidentified,butnocrystalstructurehasyetbeenregisteredor depositedinaproteindatabank.Thisreportdescribesresultsforcomparisonsofstructureforhuman andplantMPC1/2heterodimerhomologymodels.Keycysteineresiduesareidentifiedforpyruvate andblockerbindingandformationofthiohemiacetalorMichaeladditionbonds.Evidenceisprovided foranalternatingaccessmodelinhuman,mouseear-cress,castorandcommonbeans,andcorn. KeywoRDS Arabidopsis Thaliana, Homo Sapien, In Silico, Phaseolus Vulgaris, Protein Homology, Protein Protein Docking, Pyruvate Docking, Ricinus Communis, Zea Mays

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线粒体丙酮酸载体1和2异源二聚体，植物和人类复合物模型:结构和转运体结合特性的比较

Theplantandhumanmitochondrialpyruvatecarrier(MPC)hadbeenstudiedinthe1970s-1990s providingmanypredictionsonfunctionalproteinstructureandmechanismsofsubstratebinding。Genes forhumanandplantMPChavebeenidentified，butnocrystalstructurehasyetbeenregisteredor depositedinaproteindatabank。Thisreportdescribesresultsforcomparisonsofstructureforhuman andplantMPC1/2heterodimerhomologymodels。Keycysteineresiduesareidentifiedforpyruvate andblockerbindingandformationofthiohemiacetalorMichaeladditionbonds。Evidenceisprovided foranalternatingaccessmodelinhuman，mouseear-cress，castorandcommonbeans，andcorn。关键词拟南芥，智人，In Silico，菜豆，蛋白同源性，蛋白对接，丙酮酸对接，蓖麻，玉米

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Int. J. Knowl. Discov. Bioinform.

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