Immunohistochemical expression of E-Cadherin in gastric carcinoma in Erbil city, Kurdistan Region

Abstract

Background and objectives: Gastric carcinoma is at fourth position incidence-wise and holds a second place for deaths due to cancer. The Cadherins represent an important class of the adhesiveness molecules, which play an essential role in the homotypical cell-cell adhesion and in the complex process of invasion and metastasis. The point of this study is to identify the rate of the E-Cadherin immunoexpression in gastric carcinoma in Erbil locality and investigate its association with the clinico pathological parameters. Methods: A retrospective study was carried out in Rizgary teaching hospital and private laboratories in Erbil city for the period from Jan.2018 - Jan.2020. A total of 75 formalin fixed, paraffin embedded archival tissue blocks of total or partial gastrectomy samples for gastric carcinoma cases were collected, then E-cadherin immunohistochemistry was tested. Results: Twenty-one cases (28%) were categorized as high expression for E-Cadherin immunoexpression. At the same time 38 (50.7%) of the cases were classified as low expression and 16 (21.3%) of cases were labelled with no expression. E-Cadherin status was significantly associated with the tumor type and tumor grade, in which high E-Cadherin expression about (61.9%) was demonstrated in intestinal type tumors, (38.1%) in diffuse type tumors and about (57.1%) was performed in well-moderately differentiated tumors and (42.9%) in poorly differentiated tumors. While no significant association was found between E-Cadherin expression and other clinico. Conclusions: Our result support the hypothesis that the E-Cadherin immunostain is commonly expressed in Gastric cancer, and it was significantly related with type and grade of the tumor.