Elevated serum levels of TNF-α and IL-17 in psoriatic and rheumatoid arthritis

A. Angelov, G. Vasilev, A. Yordanova, E. Ivanova-Todorova, D. Kyurkchiev, M. Ivanova
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Abstract

Psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are chronic inflammatory immune-mediated rheumatic diseases, in which cytokine dysregulation is key for pathogenesis. In terms of the specific processes involved in predominantly enthesopathic inflammation and predominantly synovial inflammation, PsA and RA are distinct disease entities. The aim of the present study was to investigate the serum cytokine expression profiles of TNF-α and IL-17 in the two inflammatory arthropathies, discussing their role in the context of disease activity assessed by means of DAS28-CRP, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The study included 32 patients with PsA, 30 with RA and 20 healthy subjects. In patients with RA and PsA, higher serum levels of both cytokines were measured compared to healthy controls, with the difference being significant, except for TNF-α for patients with PsA, whose concentration was numerically but not significantly higher compared to healthy individuals. We also recorded a significant increase in circulating TNF-α in RA versus PsA, with no difference for IL-17 in the two inflammatory joint diseases. The two studied cytokines did not show a significant difference in serum concentrations according to the state of the disease activity (DAS28- CRP < 3.2 vs. DAS28- CRP ≥ 3.2) in both PsA and RA, as well as association with clinical and laboratory parameters of activity from correlation analyses, supporting the claim that they are not useful markers for its assessment. In conclusion, both cytokines are clearly abundant in the circulation in conditions of both inflammatory arthropathies. The TNF-α and IL-17 pathways are important links and an active participant in these types of rheumatic inflammation.
银屑病和类风湿关节炎患者血清TNF-α和IL-17水平升高
银屑病关节炎(Psoriatic arthritis, PsA)和类风湿关节炎(rheumatoid arthritis, RA)是慢性炎症免疫介导的风湿性疾病,细胞因子失调是其发病的关键。就主要是骨髓瘤炎症和滑膜炎症的具体过程而言,PsA和RA是不同的疾病实体。本研究的目的是研究两种炎性关节病中血清细胞因子TNF-α和IL-17的表达谱,讨论它们在DAS28-CRP、红细胞沉降率(ESR)和c反应蛋白(CRP)评估疾病活动性中的作用。该研究包括32名PsA患者,30名RA患者和20名健康受试者。在RA和PsA患者中,与健康对照相比,两种细胞因子的血清水平均较高,差异具有显著性,但PsA患者的TNF-α浓度在数值上高于健康个体,但差异不显著。我们还记录了RA与PsA中循环TNF-α的显著增加,而IL-17在两种炎症性关节疾病中没有差异。根据疾病活动性状态(DAS28- CRP < 3.2 vs DAS28- CRP≥3.2),两种研究的细胞因子在PsA和RA中的血清浓度没有显着差异,以及与相关分析的临床和实验室活动性参数的关联,支持它们不是评估其有用标记的说法。总之,这两种细胞因子在两种炎症性关节病的循环中明显丰富。TNF-α和IL-17通路是这些类型风湿性炎症的重要环节和积极参与者。
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