EFFECT OF Salvia officinalis and Thyme Vulgaris OIL ON HEMATOLOGICAL PARAMETERS OF INDUCED GASTRIC ULCER IN MATURE FEMALE RATS

Abstract

The present study has been carried out at the department of physiology, College of Veterinary Medicine of Basrah, to evaluate the role of oil extracted from salvia officinalis and Thymus vulgaris leaves in some structural and functional characteristics of mature female rats experimentally induced with gastric ulcer.Oils of thyme and sage were extracted from dry leaves available in Basrah market by normal hexane, oils components have been analyzed in a manner GC-MAS (Gas chromatography). Gastric ulcers were induced in starved female rats by giving indomethacin orally by mouth gavage in a dose 25mg\kg for one day. The animals have been divided into seven equal groups(8 females in each group). The first group was received normal saline and served as a negative control. Second group serve as positive group that received only single dose of indomethacin, whereas third group treated with thyme crude oil for two week ,fourth group that treated with thyme dilution oil for two weeks,fifth group treated with sage crude oil for two week, sixth group treated with sage dilution oil for two weeks and seventh group treated with cimetidine for two weeks. The blood has been obtained for hematological assessment the present results: showed no changed in RBCs , PCV of female rats groups treated with thyme crude,thyme dilution, sage crude oil and cimetidine and just group treated with sage dilution caused a significant decrease in RBCs and PCV among treated group. So, the results revealed that there is no- changed in WBC in groups treated with thyme crude, thyme dilution and sage dilution ,whereas showed a decreased in gastric ulcer group, sage crude and cimetidine group. Also neutrophils existed increase significantly in all treated groups compared with control negative group ,whereas no change recorded in thyme dilution and sage crude groups compared with control negative group.