EFFECTS OF TRAMADOL ADMINISTRATION ON SOME BIOCHEMICAL PARAMETERS IN WISTER ALBINO RATS UNDER NON-INDUCTION OF PAIN

Multidisciplinary Journal for Applied Research in Engineering and Technology Pub Date : 2022-04-30 DOI:10.54228/mjaret04220002

Olisa Nwuruku Alfred, U. Ibiam, I. Emmanuel, V. Nwobodo, D. C. Chukwu, P. I. Onuegbu, C. C. Osuagwu, E. Onuh, J. Ndulaka

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Abstract

This study investigates the effect of tramadol under non-induction of pain on some biochemical parameters in albino rats. A total of 24 albino rats were randomly divided into four groups of 6 members each. Group 1 received pellet and was allowed free access to water. This was the control. Groups 2, 3 and 4 received 50, 100 and 200 mg/Kg body weight of tramadol respectively. All the administrations were via oral intubation and were done once daily for 30 days. Neurotransmitters, glutamine dehydrogenase, glutaminase, and oxidative stress markers were determined in the brain homogenate using standard methods. Liver function markers, kidney function parameters and pancreatic markers were equally determined in the serum using standard methods. The results showed that levels of serotonin, dopamine, reduced glutathione, albumin and activities of catalase, super oxide dismutase, glutathione transferase, glutathione peroxidase, glutaminase and lipase were significantly (p<0.05) lowered in rats administered tramadol only in dose dependent manner when compared with the control. The results also revealed that administration of different doses of tramadol caused significant (p<0.05) increase in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, α-amylase, glutamine dehydrogenase and levels of total bilirubin, uric acid, urea, creatinine and malondialdehyde in dose dependent manner when compared with control. These results generally revealed that intake of tramadol under non-induction of pain caused significant alterations of some biochemical markers, which could lead to health consequences

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曲马多给药对非诱导疼痛的白化大鼠生化指标的影响

本研究探讨曲马多在非诱导疼痛条件下对白化大鼠一些生化指标的影响。将24只白化大鼠随机分为4组，每组6只。第一组接受颗粒，并允许自由饮水。这是对照组。2、3、4组分别给予曲马多50、100、200 mg/Kg体重。所有给药方式均为口服插管，每日1次，连用30天。采用标准方法测定脑匀浆中的神经递质、谷氨酰胺脱氢酶、谷氨酰胺酶和氧化应激标志物。采用标准方法测定血清中肝功能指标、肾功能指标和胰腺指标。结果表明，单剂量依赖性曲马多组血清素、多巴胺、还原性谷胱甘肽、白蛋白水平及过氧化氢酶、超氧化物歧化酶、谷胱甘肽转移酶、谷胱甘肽过氧化物酶、谷氨酰胺酶和脂肪酶活性均显著低于对照组(p<0.05)。与对照组相比，不同剂量曲马多使大鼠天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、α-淀粉酶、谷氨酰胺脱氢酶活性及总胆红素、尿酸、尿素、肌酐和丙二醛水平呈剂量依赖性升高(p<0.05)。这些结果普遍表明，在非诱导疼痛的情况下摄入曲马多会导致一些生化标志物的显著改变，这可能导致健康后果

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Multidisciplinary Journal for Applied Research in Engineering and Technology

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