Lithium carbonate in the preoperative preparation of Graves' disease.

T Tsunoda, N Mochinaga, T Eto, M Yamaguchi, R Tsuchiya, M Izumi
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引用次数: 6

Abstract

Lithium carbonate was given in the preoperative preparation of 12 patients with Graves' disease, the reasons for its use being side effects of thionamide in 9 patients, insufficient control by thionamide in 1 and psychic symptoms in 2. Lithium carbonate was often used in combination with other drugs, namely; thionamide in 4 patients, beta-adrenergic blockades in 5, reserpine in 5 and glucocorticoid in 1. This preoperative control significantly decreased the mean serum T2 and T4 levels from 656 +/- 55 ng/dl to 180 +/- 16 ng/dl and from 25.9 +/- 2.1 micrograms/dl to 9.7 +/- 1.5 micrograms/dl, respectively. The only adverse effect of lithium carbonate was pollakisuria observed in one patient. All patients underwent subtotal thyroidectomy uneventfully. It is concluded that the administration of lithium carbonate alone or in combination with other drugs is an effective method of preoperatively controlling hyperthyroidism when conventional antithyroid drugs show adverse effects.

碳酸锂在Graves病术前准备中的应用。
12例Graves病患者术前准备给予碳酸锂,使用原因为硫胺副作用9例,硫胺控制不足1例,精神症状2例。碳酸锂常与其他药物合用,即;硫胺4例,β -肾上腺素能阻滞5例,利血平5例,糖皮质激素1例。术前对照显著降低了平均血清T2和T4水平,分别从656 +/- 55 ng/dl降至180 +/- 16 ng/dl和从25.9 +/- 2.1微克/dl降至9.7 +/- 1.5微克/dl。碳酸锂唯一的不良反应是在一名患者中观察到尿尿。所有患者均顺利行甲状腺次全切除术。结论:术前常规抗甲状腺药物出现不良反应时,碳酸锂单用或联用其他药物是控制甲亢的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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