Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin

D. Seiffert , J. Mimuro , R.R. Schleef , D.J. Loskutoff
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引用次数: 62

Abstract

Regulation of plasminogen activation is a key process in controlling proteolytic events in the extracellular matrix (ECM) and this regulation is achieved through the action of specific plasminogen activator (PA) inhibitors (PAIs). Type I PAI (PAI-1) is the physiological inhibitor both of urinary-type PA (u-PA) and tissue-type PA (t-PA) (Loskutoff et al., 1989) and is a major component of the ECM of cultured cells. This inhibitor may protect ECM constituents against cellular proteases and thus influence the cell migration and tissue destruction that occurs during development, inflammation and tumor metastasis. In this review, we discuss the properties of PAI-1 and the evidence that the binding of PAI-1 to ECM is mediated by serum-derived vitronectin (Vn).

1型纤溶酶原激活物抑制剂、细胞外基质和玻璃体连接蛋白的相互作用
纤溶酶原活化的调控是控制细胞外基质(ECM)蛋白水解事件的关键过程,这种调控是通过特异性纤溶酶原激活物(PA)抑制剂(PAIs)的作用来实现的。I型PAI (PAI-1)是尿型PA (u-PA)和组织型PA (t-PA)的生理抑制剂(Loskutoff et al., 1989),是培养细胞ECM的主要成分。该抑制剂可能保护ECM成分免受细胞蛋白酶的侵害,从而影响细胞在发育、炎症和肿瘤转移过程中的迁移和组织破坏。在这篇综述中,我们讨论了PAI-1的特性以及PAI-1与ECM结合是由血清源性玻璃体连接蛋白(Vn)介导的证据。
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