Levels of FGF-23, C-Reactive Protein, Alkaline Phosphatase as A Risk Factor for Renal Osteodystrophy in Chronic Kidney Disease Patients Stage IV-V

I. K. W. Trisaputra, K. G. Mulyadi Ridia, I. Suyasa, I. E. Wiratnaya, Y. Kandarini
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Abstract

The condition of CKD is closely related to the existence of systemic disorders that affect various organs, including organs that often experience effects are the kidneys and musculoskeletal. Cases of osteoporosis are often found in patients with CKD who are commonly known as having Renal Osteodystrophy, which is defined by the presence of disorders or pathological conditions in the bones associated with CKD conditions. FGF-23, CRP, ALP are markers that have been associated with the occurrence of a renal osteodystrophy. By conducting this research, it is expected to know the relationship between the three markers and the occurrence of renal osteodystrophy. This study used a case-control design with a cross-sectional method to determine the relationship between FGF-23, CRP, ALP and renal osteodystrophy. From the CKD population with or without renal osteodystrophy, the sample was selected by consecutive sampling. After that, statistical tests were carried out in the form of descriptive tests, normality tests, risk factor assessment using 2x2 cross-tabulations, and predictive analysis of proportions using logistic regression tests. FGF-23 levels > 30 pg/ml (p-value <0.001; CI = 1.4-6.7), CRP > 3 mg/L (p-value <0.001; CI = 1.3-4.8), ALP > 120 U/L (p-value <0.001; CI = 1.7-10.6) in patients with stage IV-V CKD significantly increased the risk of renal osteodystrophy. In the multivariate analysis, ALP had the most significant value compared to these three variables. Based on this study, increased serum ALP is the most influential risk factor for renal osteodystrophy, both based on bivariate and multivariate analysis.  
FGF-23、c反应蛋白、碱性磷酸酶水平是IV-V期慢性肾病患者肾性骨营养不良的危险因素
CKD的病情与影响各个器官的全身性疾病的存在密切相关,包括经常受到影响的器官是肾脏和肌肉骨骼。骨质疏松症通常见于CKD患者,通常被称为肾性骨营养不良,这是由与CKD相关的骨骼疾病或病理状况的存在所定义的。FGF-23、CRP、ALP是与肾性骨营养不良发生相关的标志物。通过本研究,希望了解这三种标志物与肾性骨营养不良发生的关系。本研究采用病例对照设计,采用横断面法确定FGF-23、CRP、ALP与肾性骨营养不良的关系。从伴有或不伴有肾性骨营养不良的CKD人群中,通过连续抽样选择样本。之后进行描述性检验、正态性检验、2x2交叉表风险因素评估、logistic回归检验比例预测分析等统计检验。FGF-23水平> 30 pg/ml (p值为3 mg/L) (p值为120 U/L (p值<0.001;CI = 1.7-10.6)显著增加了IV-V期CKD患者发生肾性骨营养不良的风险。在多变量分析中,与这三个变量相比,ALP具有最显著的价值。基于本研究,基于双因素和多因素分析,血清ALP升高是肾性骨营养不良最重要的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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