Resistin -420 C>G Polymorphism in Female Patients of Acne in Pakistan

Abstract

Acne vulgaris is an inflammatory skin disorder of pilosebaceaous units. The clinical characteristics are seborrhea, sebaceous glands, non inflammatory lesions, inflammatory lesions and severe scaring. Propionibacterium acnes are the main pathophysiological factor influencing the acne development. Resistin gene is a novel proinflammatory cytokine involved in the initiation of inflammatory disorders like cardiovascular diseases, obesity and atherosclerosis. Various SNPs have been discovered in human RETN gene which is involved in different inflammatory disorders. Purpose of this study was to analyze RETN -420 C>G polymorphism in female acne patients of Pakistani population. About 58 control female subjects and 76 acne female patients were recruited for this study. In order to examine the RETN -420 C>G polymorphism in the promoter region, PCR and RFLP techniques were used. Statistically significant P value <0.05 for the RETN -420 C>G polymorphism was obtained in genotype/alleles frequencies between acne patients and control female subjects. Significant association between genotype frequencies, disease severity and acne scars distribution among female patients was also observed. It is concluded that RETN -420 promoter polymorphism was not associated with family history and skin types; however it was significantly associated with acne pathopysiology