Prevention of adhesions by high molecular weight dextran in rats. Re-evaluation in nine experiments.

Acta chirurgica Scandinavica Pub Date : 1990-11-01
J Rozga, B Ahrén, S Bengmark
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Abstract

The efficacy of 32% dextran 70 (Hyskon) in the prevention of postoperative peritoneal adhesions was evaluated in nine different experiments in a total of 320 rats under standardised conditions. Hyskon reduced adhesion formation, only in rats that were also subjected to abrasion of the caecum. In the remaining eight experiments Hyskon was ineffective. We conclude that more extensive experimental and clinical studies are desirable before this agent is recommended for prophylaxis against adhesions; any prophylactic regimen should be tested in a wide range of experiments. In addition, analysis of the control data suggested that the stimulus for inducing adhesions in some experiments was so strong that it could not be countered by any prophylactic regimen. A new microsurgical method that resulted in a 50 per cent response and an equal number of low grade and high grade adhesions was used. This method is well suited for investigation of both the stimulatory and the inhibitory effects of a test agent.

高分子量葡聚糖对大鼠粘连的预防作用。在9个实验中重新评估。
在标准化条件下,共对320只大鼠进行9项不同实验,评估32%葡聚糖70 (Hyskon)预防术后腹膜粘连的效果。Hyskon减少了粘连的形成,仅在盲肠也受到磨损的大鼠中。在剩下的8个实验中,希斯肯是无效的。我们的结论是,在推荐该药物用于预防粘连之前,需要进行更广泛的实验和临床研究;任何预防方案都应该在广泛的实验中进行测试。此外,对对照数据的分析表明,在一些实验中,诱导粘连的刺激非常强,任何预防方案都无法抵消。一种新的显微外科手术方法,导致50%的反应和相同数量的低级别和高级别粘连被使用。这种方法非常适合于研究一种试验剂的刺激和抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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