[The improvement of the tolerance of the kidney for ischemia with the prostacyclin analog iloprost].

H J Forth, U Rebmann, H Heynemann, J Schabel, H D Pauer, G Mehlhorn, R Scharf, H J Mest
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Abstract

Operative trauma, ischemia, release of catecholamines and thermal stimuli in consequence of harvesting, preservation and transplantation deteriorate the renal capillary circulation. By crossing of tolerance limits arises an irreversible transplant damage. The conditions of our examinations were placed in this field. By pre- and postischemic application of Iloprost was demonstrable an improvement of the ischemic tolerance of the kidney. Correction of renal hemodynamics, antiplatelet action and cytoprotection are the reasons of the protective influence of Iloprost in our opinion.

前列环素类似物伊洛前列素对肾脏缺血耐受性的改善。
手术创伤,缺血,儿茶酚胺的释放和热刺激的收获,保存和移植的结果恶化肾毛细血管循环。一旦超过容忍限度,就会产生不可逆的移植损伤。我们的考试条件是在这个领域。通过化疗前和化疗后应用伊洛前列素,可以证明肾脏缺血耐受性的改善。我们认为伊洛前列素具有肾血流动力学的纠正、抗血小板作用和细胞保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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