Endogenous interferon (IFN) in patients with acute hepatitis B.

Acta medica Hungarica Pub Date : 1990-01-01
A Boron-Kaczmarska, R Zachoval, V Zachoval, F Deinhardt
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Abstract

The occurrence of serum interferon was studied in 39 patients with acute viral hepatitis B. Antiviral activity of interferon in serum was determined by measuring the inhibition of the CPE of vesicular stomatitis virus on bovine kidney cells (MDBK). Among these patients only 5 (12.8%) had detectable serum interferon level during the first week of hospitalization. The antiviral activity of the interferon-positive sera was low (5-10 IU/ml).

内源性干扰素(IFN)在急性乙型肝炎患者中的应用。
通过测定水疱性口炎病毒CPE对牛肾细胞(MDBK)的抑制作用,研究了39例急性乙型病毒性肝炎患者血清中干扰素的发生情况。在这些患者中,只有5例(12.8%)在住院第一周检测到血清干扰素水平。干扰素阳性血清抗病毒活性低(5 ~ 10 IU/ml)。
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