I.A. Ramírez-Galindo, A. Alías-Melgar, M. Pelayo-Nieto, E. Linden-Castro, J.A. Morales-Covarrubias, F. Bertrand-Noriega, A. González-Serrano, R. Cortez-Betancourt
{"title":"Correlación entre testosterona total y resultado histopatológico en pacientes sometidos a prostatectomía radical retropúbica","authors":"I.A. Ramírez-Galindo, A. Alías-Melgar, M. Pelayo-Nieto, E. Linden-Castro, J.A. Morales-Covarrubias, F. Bertrand-Noriega, A. González-Serrano, R. Cortez-Betancourt","doi":"10.1016/j.uromx.2016.03.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The role of hormonal influence on prostate cancer is reflected mainly on the effect of androgen deprivation therapy in metastatic disease. Nevertheless, in localized prostate cancer there is increasing evidence of a more aggressive clinical course directly correlated with low serum total testosterone levels.</p></div><div><h3>Aim</h3><p>To analyze the correlation between preoperative serum total testosterone levels and the histologic grade obtained through transrectal biopsy and the definitive anatomopathologic report in patients that underwent open radical retropubic prostatectomy at a tertiary care hospital in Mexico City.</p></div><div><h3>Methodology</h3><p>A retrospective, observational, analytic study was conducted that included 52 patients operated on with open radical retropubic prostatectomy at a tertiary care hospital in Mexico City. A correlation was established between low serum total testosterone levels and the Gleason score obtained through transrectal biopsy and the definitive histopathologic report, as well as surgical margin status.</p></div><div><h3>Results</h3><p>A statistically significant association was found between low serum total testosterone levels and a Gleason score of 8 or higher in the definitive histopathologic report after radical prostatectomy (<em>P</em> <!-->=<!--> <!-->.00165), positive surgical margins (<em>P</em> <!-->=<!--> <!-->.0148), and the presence of locally advanced disease after the analysis with the Fisher's exact test (<em>P</em> <!-->=<!--> <!-->.0110).</p></div><div><h3>Conclusions</h3><p>The present study showed positive results in relation to the influence of total testosterone on the histopathologic variables that determine cancer-specific survival in localized prostate cancer, consistent with numerous case series reported in the literature.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2016.03.001","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista mexicana de urologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2007408516000331","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background
The role of hormonal influence on prostate cancer is reflected mainly on the effect of androgen deprivation therapy in metastatic disease. Nevertheless, in localized prostate cancer there is increasing evidence of a more aggressive clinical course directly correlated with low serum total testosterone levels.
Aim
To analyze the correlation between preoperative serum total testosterone levels and the histologic grade obtained through transrectal biopsy and the definitive anatomopathologic report in patients that underwent open radical retropubic prostatectomy at a tertiary care hospital in Mexico City.
Methodology
A retrospective, observational, analytic study was conducted that included 52 patients operated on with open radical retropubic prostatectomy at a tertiary care hospital in Mexico City. A correlation was established between low serum total testosterone levels and the Gleason score obtained through transrectal biopsy and the definitive histopathologic report, as well as surgical margin status.
Results
A statistically significant association was found between low serum total testosterone levels and a Gleason score of 8 or higher in the definitive histopathologic report after radical prostatectomy (P = .00165), positive surgical margins (P = .0148), and the presence of locally advanced disease after the analysis with the Fisher's exact test (P = .0110).
Conclusions
The present study showed positive results in relation to the influence of total testosterone on the histopathologic variables that determine cancer-specific survival in localized prostate cancer, consistent with numerous case series reported in the literature.
期刊介绍:
Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.