4.1 Strain-Promoted Azide–Alkyne Cycloaddition (SPAAC): Background, Substrate Preparation, and Reactivity

Abstract

This chapter discusses the creative synthetic approaches to azides and cycloalkynes, provides the rationale for controlling SPAAC reactivity through tuning cycloalkyne and azide backbone modifications, and highlights research on nitrone cycloadditions with cycloalkynes. This synthetic and knowledge toolset will help in the design of better cycloalkynes and their partners to answer challenging research questions and aid the development of new applications.