[Cisplatin-induced nephrotoxic side effects of cytostatic chemotherapy of testicular tumors].

Abstract

The nephrotoxic side effect of Cis-platin was investigated in 38 patients with testicular tumors. The serum creatinine and the creatinine clearance served as function parameters. A temporary or permanent restriction of the creatinine clearance developed 31 of 38 patients during the therapy period. Increased creatinine levels were found in 6 patients. Two of them got into a chronic renal insufficiency. A pretherapeutic risk group of patients or a precarious dose of Cis-platin could not be found out.