[Effects of interferon on immunoglobulin production in normal subjects and in patients with selective IgA deficiency. An "in vitro" study].

Abstract

The ability of Interferon (IFN) alpha, beta and gamma to induce IgA production from IgA deficient patients lymphocytes was tested "in vitro". In affected patients IgG and IgM production was similar to the normal cases but no effect on IgA production was observed. In normal cases variable concentration of alpha- beta- and gamma-IFN resulted in different immunoglobulin production. In IgA selective deficiency a low number of SmIgA bearing cells and defective transformation in IgA-plasma cells was noted as possible primary defect.