GLYCEMIC AND ATHEROGENIC STATUS AMONG DUHOK UNIVERSITY STAFF RECOVERED FROM COVID-19 WITH NO COMORBIDITIES

Bishkova SALIH KHALID, Suad Yousif Alkass
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Abstract

Background: While most infected people recovered completely from COVID-19 within a few weeks, a considerable proportion continues to experience symptoms after their initial recovery similar to SARS survivors. Intensive ongoing research has shed light on the pathogenesis of COVID-19 and the extent of damages caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but the intermediate and long-term complications remain unclear. The objective of this study is to evaluate the glycemic and atherogenic status in non-hospitalized and recovered covid-19 individuals without underlying diseases prior to the infection. Methods: A total of 200 apparently healthy subjects from all the staff of Duhok University were enrolled in this case-control study. The subjects were divided into two groups. Group 1 included 107 subjects non-hospitalized recovered from covid-19 at more than 3 months after infection which was proved by RT-PCR and Group 2 included 93 healthy subjects who have not been infected with covid-19 as control group. Venous blood samples were collected and analyzed for glycemic and atherogenic related parameters. Results: There was no significant differences in blood pressure, glycemic and atherogenic status between previously infected and not infected subjects. However triglycerides (TG) and cardio-protective index (CPI) were slightly and non-significantly higher and low density lipoprotein (LDL), total cholesterol (TC) and atherogenic index of plasma (AIP) lower in previously infected subjects. Also, fasting plasma insulin (FPI), Homeostasis model assessment-insulin resistance (HOMA-IR) and risk of atherogenicity were slightly higher in the infected males, younger ages, older ages and obese subjects. Conclusions: There are no long-term effects of COVID-19 on the glycemic and atherogenic status of the recovered not hospitalized patients.
杜胡克大学工作人员的血糖和动脉粥样硬化状态从COVID-19中恢复,无合并症
背景:虽然大多数感染COVID-19的人在几周内完全康复,但相当大比例的人在最初康复后继续出现类似于SARS幸存者的症状。正在进行的深入研究已经揭示了COVID-19的发病机制和严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)造成的损害程度,但中期和长期并发症仍不清楚。本研究的目的是评估感染前无基础疾病的未住院和康复的covid-19患者的血糖和动脉粥样硬化状态。方法:采用病例对照研究,选取杜克大学全体教职员工中外表健康的200人。受试者被分成两组。第1组纳入经RT-PCR证实感染后3个月以上未住院康复的107例患者,第2组纳入未感染covid-19的健康受试者93例作为对照组。采集静脉血,分析血糖和动脉粥样硬化相关参数。结果:在先前感染和未感染的受试者之间,血压、血糖和动脉粥样硬化状态无显著差异。然而,在先前感染的受试者中,甘油三酯(TG)和心脏保护指数(CPI)略有升高,而低密度脂蛋白(LDL)、总胆固醇(TC)和血浆动脉粥样硬化指数(AIP)较低。此外,空腹血浆胰岛素(FPI)、稳态模型评估-胰岛素抵抗(HOMA-IR)和动脉粥样硬化的风险在感染的男性、年轻人、老年人和肥胖受试者中略高。结论:COVID-19对未住院康复患者的血糖和动脉粥样硬化状态无长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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