Alpha-amylase activity of tannin isolated from Terminalia chebula

S. Mukherjee, A. Mitra, S. Dey, G. Thakur
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引用次数: 5

Abstract

One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100µg/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.
诃子单宁α -淀粉酶活性研究
治疗2型糖尿病的一个重要方法是降低餐后血糖升高。这可以通过抑制某些碳水化合物水解酶如-淀粉酶来实现。本文首次以猪胰淀粉酶和马铃薯淀粉为底物,研究了从大黄果醇提物中分离得到的单宁的抑菌作用。结果表明,当单宁浓度为100µg/ml时,抑制率最高(52%)。结果与阿卡波糖相当,阿卡波糖是一种非常有效的降糖药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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