3PC-067 Abstract withdrawn

Abstract

Background Management of the anticancer treatments remainders is improved thanks to the centralisation of preparations. In our unit, remainders stored at 4°C are placed in transfer containers kept in a refridgerator. Remainders are regularly exposed to ambient temperatures. Today, no transfer system can respect the cold chain of remainders. Purpose Improvement in practices and respect of the anticancer product’s cold chain. Material and methods A follow-up of container’s temperature evolution was carried out over a period of 3 hours, simulating the routine activity: three successive exposures of the container 20 min at ambient temperature followed by 40 min in a refridgerator. These measurements were repeated three times with and without refrigerated eutectic plates for a total of 1080 measurement points. A comparison of temperature’s evolution was made with and without eutectic plates. The average of each measurement point, the SD as well as the median and average over the study period, were calculated. Results The maximum temperatures in the containers were 12.1°C without eutectic plates and 11.1°C with eutectic plates. The remainders from the refridgerator are better preserved thanks to the eutectic plates. In addition, eutectic plates decrease temperature variations in the container with a SD of 2.4°C without ice bread and 1.4°C with eutectic plates. However, the average temperatures in the container were 8.6°C with eutectic plates versus 7.8°C without eutectic plates, and the median was 8.7°C with eutectic plates and 7.5°C without eutectic plates. The temperature of the container with eutectic plates is higher than that without eutectic plates, which is explained by the fact that the container cools less quickly with an eutectic plate. Conclusion Eutectic plates reduce temperature variations of containers for a half-day of activity but do not offer a satisfactory solution for controlling the cold chain. In the future, industries should provide a solution to this problem to improve the quality of cyotoxic preparations. References and/or acknowledgements BPP, AFSSAPS 2007. No conflict of interest.