Computer Simulations Of Three-dimensional Propagation In Ventricular Myocardium. The Effects Of Intramural Fiber Rotation And Resistive Inhomogeneity

Abstract

Three-dimensional membrane-based simulations of action potential propagation in ventricular myocardium were performed. Specifically, the effects of the intramural rotation of the fiber axes and resistive inhomogeneity on the pattern of activation were examined. Two models were built, with 28,977 microscopic elements arranged in rectangular parallelpipeds in each model. Simulations used the nonlinear Ebihara and Johnson membrane equations for the fast sodium current. Constructed models had histologic features of ventricular myocardium. All simulations were performed on an IBM 3090 at the Utah Supercomputer Institute.