Progesterone for Prevention of Preterm Birth

Michelle J. Khan, Donna M. Neale
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引用次数: 11

Abstract

Preterm birth is a major cause of perinatal mortality and morbidity. It is also the main directed cause of neonatal death globally (1) . Preterm birth is responsible for more than 80% of neonatal deaths and 50% of long term morbidity in the surviving infants (1-3) . Preterm birth rates have been rising over the past 3 decades. The worldwide incidence of preterm birth is 9.6 % with the highest rate occurs in the least developed regions (4) . The increase in assisted reproductive technologies, labor induction or elective cesarean section during preterm period may be responsible for these high rates (2) . Various risk factors are associated with preterm birth but only half of them can be identified (5) . Although there are many interventions to prevent or treat preterm births, none of them appears to be efficacious (6) . Recent evidences showed that progesterone supplementations are helpful to prevent preterm birth. This article pays attention to the role of progesterone for the prevention of preterm birth.
黄体酮预防早产
早产是围产期死亡和发病的主要原因。它也是全球新生儿死亡的主要直接原因(1)。早产是80%以上新生儿死亡和50%存活婴儿长期发病率的原因(1-3)。在过去的30年里,早产率一直在上升。全球早产发生率为9.6%,最不发达地区的早产发生率最高(4)。辅助生殖技术、引产或早产期间选择性剖宫产的增加可能是造成这些高发生率的原因(2)。各种风险因素与早产有关,但只有一半可以确定(5)。虽然有许多干预措施可以预防或治疗早产,但似乎没有一种是有效的(6)。最近的证据表明,补充黄体酮有助于预防早产。本文就黄体酮在预防早产中的作用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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