{"title":"Progesterone for Prevention of Preterm Birth","authors":"Michelle J. Khan, Donna M. Neale","doi":"10.1097/01.PGO.0000413593.90081.6f","DOIUrl":null,"url":null,"abstract":"Preterm birth is a major cause of perinatal mortality and morbidity. It is also the main directed cause of neonatal death globally (1) . Preterm birth is responsible for more than 80% of neonatal deaths and 50% of long term morbidity in the surviving infants (1-3) . Preterm birth rates have been rising over the past 3 decades. The worldwide incidence of preterm birth is 9.6 % with the highest rate occurs in the least developed regions (4) . The increase in assisted reproductive technologies, labor induction or elective cesarean section during preterm period may be responsible for these high rates (2) . Various risk factors are associated with preterm birth but only half of them can be identified (5) . Although there are many interventions to prevent or treat preterm births, none of them appears to be efficacious (6) . Recent evidences showed that progesterone supplementations are helpful to prevent preterm birth. This article pays attention to the role of progesterone for the prevention of preterm birth.","PeriodicalId":208056,"journal":{"name":"Postgraduate Obstetrics & Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Postgraduate Obstetrics & Gynecology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/01.PGO.0000413593.90081.6f","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
Preterm birth is a major cause of perinatal mortality and morbidity. It is also the main directed cause of neonatal death globally (1) . Preterm birth is responsible for more than 80% of neonatal deaths and 50% of long term morbidity in the surviving infants (1-3) . Preterm birth rates have been rising over the past 3 decades. The worldwide incidence of preterm birth is 9.6 % with the highest rate occurs in the least developed regions (4) . The increase in assisted reproductive technologies, labor induction or elective cesarean section during preterm period may be responsible for these high rates (2) . Various risk factors are associated with preterm birth but only half of them can be identified (5) . Although there are many interventions to prevent or treat preterm births, none of them appears to be efficacious (6) . Recent evidences showed that progesterone supplementations are helpful to prevent preterm birth. This article pays attention to the role of progesterone for the prevention of preterm birth.