EMERGING DRUGS: A SYSTEMATIC REVIEW OF THE POTENTIAL ANTIVIRAL ACTIONS OF AZITHROMYCIN.

Revista Intertox de Toxicologia, Risco Ambiental e Sociedade Pub Date : 2021-02-02 DOI:10.22280/REVINTERVOL14ED1.479

L. Corrêa, Juliana Weckx Peña-Muñoz, Paula A. Faria Waziry, M. A. Nicoletti, E. Ricci, Vinicius De Barros Hirota, A. Fukushima

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Abstract

INTRODUCTION: Viruses that cause respiratory infections, commonly called "flu," kill thousands of people annually. In 2020, the World Health Organization declared a pandemic state due to COVID-19 infection. The virus that causes COVID-19, SARS-CoV-2, causes acute respiratory syndrome, which currently has no established treatment and is capable of widespread dissemination. OBJECTIVE: Systematically provide evidence of azithromycin’s pleiotropic antiviral effects. METHODOLOGY: Pubmed database search for articles related by the terms: “antiviral” and “azithromycin”. RESULTS: Although there are no clinical protocols that can clearly evaluate the antiviral effectiveness of azithromycin, 73,3% of the articles found concluded that azithromycin has potential pleiotropic antiviral activity that should be further investigated. CONCLUSION: Azithromycin has the potential to be repurposed as an antiviral drug, however, further studies are needed for targeting the drug’s action against specific viral pathogens as well as double-blind, randomized clinical trials. Keywords: Emerging drugs. Azithromycin. Antiviral. Immunomodulatory effects

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新兴药物:阿奇霉素潜在抗病毒作用的系统综述。

导读:引起呼吸道感染的病毒，通常被称为“流感”，每年导致数千人死亡。2020年，由于新冠肺炎感染，世界卫生组织宣布进入大流行状态。引起COVID-19的病毒SARS-CoV-2会引起急性呼吸综合征，目前尚无既定的治疗方法，并且能够广泛传播。目的:系统地提供阿奇霉素多效抗病毒作用的证据。方法:Pubmed数据库搜索与“抗病毒”和“阿奇霉素”相关的文章。结果:虽然目前尚无明确评价阿奇霉素抗病毒效果的临床方案，但73.3%的文献得出结论认为阿奇霉素具有潜在的多效抗病毒活性，有待进一步研究。结论:阿奇霉素有潜力成为一种抗病毒药物，但其针对特定病毒病原体的作用还需要进一步的研究和双盲随机临床试验。关键词:新兴药物;阿奇霉素。抗病毒药物。免疫调节作用

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Revista Intertox de Toxicologia, Risco Ambiental e Sociedade

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