Alterations In Lipid Profile Of Patients With Advanced Cervical Cancer

C. Okonkwo, O. Amegor, Ol Ogemuno
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引用次数: 1

Abstract

Background The changes in lipid profile have long been associated with cancer because lipids play key role in maintenance of cell integrity. Aims . The study evaluated alterations in plasma lipid profile in patients with advanced squamous cervical cancer. Materials And Method This hospital-based study included 30 cervical cancer patients, with 30 controls. Plasma lipids including: Total cholesterol (TC), Low Density Lipoprotein cholesterol (LDL ), High Density Lipoprotein cholesterol C (HDL ) and triglycerides (TAG) were analyzed by spectrophotometric kits. C Student's t-test was performed to compare mean values of the parameters. Results A significant decrease in plasma total cholesterol, HDLC and triglycerides was observed in cervical cancer patients as compared to the controls. The LDL lipid fraction was however higher in the cases than in the C controls. Also there was direct relationship between reduced lipid levels and cervical cancer progression, this was statistically significant. Conclusion The lower levels of plasma cholesterol and other lipid constituents in patients might be due to low levels of antioxidants which is a common finding among cancer patients, however this would have to be confirmed by evaluating the anti-oxidant levels of these patients. There is also the need to conduct a study with a much larger sample size. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in cervical cancer patients as a means of monitoring and evaluating such patients. Key Words: Lipid profile, cancer, cervix, spectophotometry, Benin City.
晚期宫颈癌患者脂质谱的改变
长期以来,脂质谱的变化与癌症有关,因为脂质在维持细胞完整性方面起着关键作用。目标该研究评估了晚期鳞状宫颈癌患者血浆脂质谱的改变。材料与方法本研究以医院为基础,纳入30例宫颈癌患者,对照组30例。用分光光度法分析血浆脂质包括:总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇C (HDL)和甘油三酯(TAG)。C采用Student’st检验比较各参数的均值。结果宫颈癌患者血浆总胆固醇、HDLC和甘油三酯水平较对照组明显降低。然而,与C组相比,这些病例的LDL脂质分数更高。血脂水平降低与宫颈癌进展之间也有直接关系,这在统计学上是显著的。结论:患者血浆胆固醇和其他脂质成分水平较低可能是由于抗氧化剂水平较低,这在癌症患者中是一种常见的发现,但这必须通过评估这些患者的抗氧化剂水平来证实。还需要进行一项样本量大得多的研究。研究结果强烈要求对宫颈癌患者血浆脂质谱的改变进行深入研究,作为监测和评估此类患者的手段。关键词:脂质谱,癌症,子宫颈,分光光度法,贝宁市
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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