Alteration of brain stem auditory evoked potentials after intracerebroventricular administration of met-enkephalin in rabbits.

Acta physiologica Polonica Pub Date : 1990-01-01
K Gregorowicz, S Kosiński, W Z Traczyk
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引用次数: 0

Abstract

Brainstem auditory evoked potentials (BAEPs) were elicited by binaural click stimulation and recorded from the rabbits with chronically implanted electrodes and a cannula for intracerebroventricular injection (i.c.v.). 400 BAEPs were averaged off line. The registration was carried out before and after i.c.v. injection of met-enkephalin (2.5 or 25 nmol), naloxone (20 micrograms), or i.v. injection of morphine (1.0, 2.0, 5.0 mg/kg b.w.). Enkephalin caused shortening of interpeak latency time, naloxone caused its lengthening, while the effect of morphine was not unidirectional. Enkephalin caused increase in the surface area below the negative peaks located in the range of 4.5-7.5 ms from the first positive peak, naloxone caused its decrease while the effect of morphine was also in this respect not unidirectional. It is concluded that opiate receptors are involved in the modulation of the auditory brainstem responses.

脑室注射脑啡肽对兔脑干听觉诱发电位的影响。
长期植入电极和脑室内注射(i.c.v)插管的家兔,通过双耳点击刺激诱发脑干听觉诱发电位(BAEPs)。脱机平均baep为400。分别在静脉注射脑啡肽(2.5或25 nmol)、纳洛酮(20微克)或吗啡(1.0、2.0、5.0 mg/kg b.w.)前后进行登记。脑啡肽引起峰间潜伏期缩短,纳洛酮引起峰间潜伏期延长,而吗啡的作用不是单向的。脑啡肽引起负峰下表面积增加,位于第一个正峰4.5 ~ 7.5 ms范围内,纳洛酮引起负峰下表面积减少,吗啡在这方面的作用也不是单向的。结果表明,阿片受体参与了听觉脑干反应的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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