[An analysis of the age-related characteristics of the analgesic action of clofelin].

Farmakologiia i toksikologiia Pub Date : 1991-11-01
E T Zlenko, E M Demchenko
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Abstract

In the experiments on rats of different ages it was found that the analgesic effect of clopheline was stronger in the adult animals as compared with 1-month-old ones. Against the background of the operative trauma (laparotomy) the inversion of the effect occurs, namely clopheline exerts a more potent analgesic effect of clopheline in young animals. Simultaneously in the young animals there is observed suppression of the memory processes based on the nociceptive reinforcement. The potentiation of the analgesic effect of clopheline in 1-month-old animals is followed by an increase of the activity of Na+, K(+)-ATPase in the brain cortex the degree of which (two times) corresponds to the rise of the analgesic effect.

[clofelin镇痛作用的年龄相关性分析]。
在不同年龄的大鼠实验中发现,与1月龄的大鼠相比,氯酚林对成年大鼠的镇痛作用更强。在手术创伤(开腹手术)的背景下,这种效应发生了反转,即在幼龄动物中,clopheline比clophine具有更强的镇痛作用。同时,在幼龄动物中,观察到基于伤害性强化的记忆过程受到抑制。氯酚林在1月龄大鼠的镇痛作用增强后,脑皮层内Na+, K(+)- atp酶活性增加,其程度(2倍)对应于镇痛作用的增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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