Chemistry of Secondary Metabolites

Abdul Kader Mohiuddin
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引用次数: 4

Abstract

Medicinal plants, are known to deliver a wide scope of Plant Secondary Metabolites (PSMs) connected as bug sprays, medications, colors and poisons in farming, prescription, industry and bio-fighting in addition to bio-fear mongering, separately. Be that as it may, creation of PSMs is for the most part in little amounts, so we have to discover novel approaches to increment both amount and nature of them. Luckily, biotechnology proposes a few choices through which secondary metabolism in plants can be built in imaginative approaches to: 1) over-produce the valuable metabolites, 2) down-produce the poisonous metabolites, 3) produce the new metabolites. Secondary metabolites are extensively characterized as natural products integrated by a life form that is not basic to help development and life. The plant kingdom fabricates more than 200,000 unmistakable chemical compounds, a large portion of which emerge from particular metabolism. While these compounds assume critical jobs in interspecies challenge and safeguard, many plant natural products have been abused for use as prescriptions, scents, flavors, supplements, repellants, and colorants. In spite of this immense chemical decent variety, numerous secondary metabolites are available at low focuses in plant a, taking out yield based assembling as methods for achieving these imperative products. The basic and stereo chemical unpredictability of particular metabolites frustrates most endeavors to get to these compounds utilizing chemical blend. Albeit local plants can be built in amass target pathway metabolites. This Update gives a concise outline of designing plant secondary metabolism in microbial frameworks. We quickly diagram biosynthetic pathways intervening arrangement of the real classes of natural products with an accentuation on high-esteem terpenoids, alkaloids, phenylpropanoids, and polyketides. We additionally feature basic topics, techniques, and provoke hidden endeavors to reproduce and build these pathways in microbial hosts. We center mostly around again biosynthetic methodologies in which plant specific metabolites are combined straightforwardly from sugar feed stocks instead of enhanced forerunners or intermediates.
次生代谢物化学
药用植物,已知提供广泛的植物次生代谢物(psm),与杀虫剂、药物、颜色和毒素有关,在农业、处方、工业和生物战斗中,除了生物恐惧贩子之外,还单独存在。尽管如此,psm的创建在很大程度上是少量的,因此我们必须发现新的方法来增加它们的数量和性质。幸运的是,生物技术提出了一些选择,通过这些选择,植物的次级代谢可以以富有想象力的方式建立:1)过量产生有价值的代谢物,2)减少产生有毒的代谢物,3)产生新的代谢物。次生代谢物被广泛地描述为一种由生命形式整合的天然产物,它不是帮助发育和生命的基础。植物界制造了超过20万种不可辨认的化合物,其中很大一部分来自特定的新陈代谢。虽然这些化合物在物种间的挑战和保护中起着重要的作用,但许多植物天然产物已被滥用为处方、气味、香料、补充剂、驱虫剂和着色剂。尽管这种巨大的化学物质种类繁多,但在植物a中,许多次生代谢物在低焦点处可用,以产量为基础的组装作为获得这些重要产品的方法。特定代谢物的基本和立体化学不可预测性使大多数利用化学混合物获得这些化合物的努力受挫。虽然当地植物可以在目标途径中积累代谢产物。本更新给出了在微生物框架中设计植物次生代谢的简明概述。我们快速绘制了生物合成途径,干预了天然产物的真正类别,重点是高价值的萜类,生物碱,苯丙类和聚酮类。此外,我们还介绍了基本的主题、技术,并激发了在微生物宿主中复制和构建这些途径的隐藏努力。我们主要围绕着生物合成方法,在这种方法中,植物特定的代谢物直接从糖原料中合成,而不是从增强的前体或中间体中合成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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