Management of intraductal papillary and mucinous pancreatic neoplasms

Alexandru Năstase, A. Trofin, M. Zabara, Ramona Cadar, Oana Lovin, Anda Năstase, G. Balan, Corina Ursulescu-Lupașcu, L. Marian, C. Lupașcu
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Abstract

Management of intraductal papillary and mucinous pancreatic neoplasms. Mucinous and papillary pancreatic cystic neoplasm is a controversial pathology both from a diagnostic point of view and from a management point of view. These recommendations will include diagnostic modalities and criteria (endoscopic, imaging and histopathological), conservative management of cystic pancreatic, mucinous and papillary neoplasm and its absolute and relative surgical indications. High risk factors (high risk stigmata) for which surgery is indicated without further exploration are positive cytology for malignancy, jaundice, dilation of the main pancreatic duct over 10 mm in diameter and the presence of the wall nodule over 5 mm. For patients with a diameter of the main pancreatic duct between 5 and 9.9 mm or a cyst larger than 4 cm, surgery has a relative indication, and for asymptomatic patients with a cyst smaller than 4 cm without parietal nodules, a Conservative management is more appropriate.Our goal is to develop a protocol based on the new European recommendations published by the European Study Group on Cystic Pancreatic Tumors, in order to facilitate the early diagnosis and treatment of patients. We also want to sensitize the specialists and make them aware of the need to develop centers dedicated to hepato-biliary-pancreatic pathology and to improve the logistical means.
导管内乳头状及粘液性胰腺肿瘤的治疗
导管内乳头状及粘液性胰腺肿瘤的治疗。胰腺粘液和乳头状囊性肿瘤是一个有争议的病理无论是从诊断的角度和从管理的角度来看。这些建议将包括诊断方式和标准(内窥镜、影像学和组织病理学)、囊性胰腺、粘液和乳头状肿瘤的保守治疗及其绝对和相对手术指征。高危因素(高危污斑)如恶性肿瘤细胞学阳性、黄疸、主胰管扩张直径超过10mm和壁结节超过5mm,无需进一步探查即可行手术。对于主胰管直径在5 - 9.9 mm之间或囊肿大于4cm的患者,手术有相对适应症,对于囊肿小于4cm且无壁结节的无症状患者,保守治疗更为合适。我们的目标是根据欧洲囊性胰腺肿瘤研究小组发布的新欧洲建议制定一项方案,以促进患者的早期诊断和治疗。我们也希望提高专家的敏感度,让他们意识到需要建立专门的肝胆胰病理中心,并改善后勤手段。
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