A Study of Bone Formation Subsequent to Intramedullary Fluid Pressure Fluctuations in Young and Old Rats

2022 IEEE Sensors Pub Date : 2022-10-30 DOI:10.1109/SENSORS52175.2022.9967229

M. L. Haider, Danyah Nashawi, Ziyu Chen, Mohammad Salman Parvez, A. S. Sanchez, Teresa Le, R. Prisby, J. Lee

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Abstract

Osteoporosis is a major health care concern. In addition to medication, mechanical loading (e.g., exercise) can augment bone mass to alleviate or delay osteoporosis. Reports in the literature indicate that the stimuli initiating bone remodeling with mechanical loading are fluctuations in intramedullary pressure and interstitial fluid flow. Methodologies designed to altered intramedullary pressure and fluid flow involve infection susceptible and external oscillatory equipment. We report preliminary data indicating enhanced bone formation in rat femora by use of polydimethylsiloxane (PDMS) based pressure modulating micropump, which alters intramedullary pressure. These pressure alterations are sensed and recorded via a wireless pressure sensor system for real-time measurement of bone intrameduallry pressure. With only 10 minutes of pressure fluctuation and 7 days of recovery, new bone volume formation in the rats tended (p=0.09) to be higher in femora receiving pressure modulation vs. the contralateral control bone. These results suggest that our system may be efficacious in augmenting bone mass.

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幼龄和老年大鼠髓内液压力波动后骨形成的研究

骨质疏松症是一个主要的保健问题。除药物外，机械负荷(如运动)可以增加骨量以减轻或延缓骨质疏松症。文献报道表明，在机械负荷下启动骨重塑的刺激因素是髓内压力和间质液流量的波动。设计用于改变髓内压力和流体流动的方法涉及易感染和外部振荡设备。我们报告的初步数据表明，使用基于聚二甲基硅氧烷(PDMS)的压力调节微泵可以改变髓内压力，从而增强大鼠股骨骨形成。这些压力变化通过无线压力传感器系统感知和记录，用于实时测量骨内压力。压力波动时间仅为10分钟，恢复时间为7天，与对侧对照骨相比，接受压力调节的股骨新生骨体积形成倾向于(p=0.09)更高。这些结果表明，我们的系统可能是有效的增加骨量。

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2022 IEEE Sensors

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