Peripheral Biomarkers in Multiple Sclerosis Patients Treated with Interferon-Beta

Andreia Monteiro, A. Mafalda Fonseca, A. Paiva
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引用次数: 1

Abstract

Multiple sclerosis is a relapsing and eventually progressive disorder of the central nervous system that continues to challenge researchers who try to understand the pathogenesis of the disease and prevent its progression. Interferon-beta is the most widely prescribed treatment for MS. Peripheral blood seems to mirror the immunological disturbances that underlie MS, which could represent the migration patterns between periphery and other tissues according to the clinical phase of the disease. Based on this assumption, several studies point to significant alterations in peripheral blood homeostasis of different subpopulations of T cells, like γδ T cells or Th1, Th2 and Th17 functional subsets; of B cells subpopulations; and of innate cells like monocytes and dendritic cells. The main goal of this chapter is to make an in-depth review of the major findings described in the literature that correlate specific alterations on different leukocytes subpopulations with disease status, and which therefore have the potential to constitute a peripheral biomarker of disease progression.
干扰素治疗多发性硬化症患者的外周生物标志物
多发性硬化症是一种反复发作并最终进展的中枢神经系统疾病,它继续挑战着试图了解疾病发病机制并防止其发展的研究人员。干扰素- β是MS最广泛使用的治疗方法。外周血似乎反映了MS背后的免疫紊乱,它可以根据疾病的临床阶段代表外周和其他组织之间的迁移模式。基于这一假设,一些研究指出了不同T细胞亚群(如γδ T细胞或Th1、Th2和Th17功能亚群)外周血稳态的显著改变;B细胞亚群;以及先天细胞,如单核细胞和树突状细胞。本章的主要目的是深入回顾文献中描述的主要发现,这些发现将不同白细胞亚群的特异性改变与疾病状态相关联,因此有可能构成疾病进展的外周生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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