Microrna-1/206 Target both Monocarboxylate Transporter(MCT)-4 and Vascular Endothelial Growth Factor(VEGF)Genes Leading to Inhibition of Tumor Growth

Abstract

Colorectal cancer is one of the most common types of cancer in the world, and its incidence is mostly influenced by lifestyle factors. Despite having a much smaller role, genetics also affects the susceptibility and development of colorectal cancer. The aim of the present study is to investigate the regulatory functions of candidate microRNAs (miRs) 1 and 206 in the context of solute carrier family 16 member 3 (SLC16A3) and vascular endothelial growth factor (VEGF) expression. To achieve this, 24 oncogenes targeted by miR-1 and miR-206 were analyzed via GeneMANIA. The miRTarBase database was then employed to ascertain the nature of the miR-oncogene relationship. Our findings illustrate that miR-1/206 indirectly reduce CRC growth and infiltration by targeting the both the SLC16A3 and VEGF genes. Moreover, miR-1/206 targets the VEGF gene to reduce tumor angiogenesis and vasculature. Conclusively, the results of the current study illustrate a novel regulation pathway in CRC cells, suggesting new potential lines of CRC therapy.