Chitosan-coated gold nanocomposites loading with cisplatin for potential use in cancer therapy

Abstract

This paper discusses the synthesis of nanocomposites based on chitosan-coated gold nanoparticles (CS-AuNPs) and the loading with cisplatin drug (CisPt). Limited studies were performed on the evaluation of AuNPs functionalized with biopolymers and conjugated with CisPt. The loading of the CS-AuNPs with cisplatin was performed in order to obtain drugs delivery systems for cancer therapy. The obtained CS-AuNPs proved to be stable, with a slight agglomeration tendency (PI of 0.302) and a hydrodynamic diameter of 85 nm. The CisPt loading in the nanocomposites was confirmed by UV-vis spectroscopy.