The NMR blood test for cancer: current status.

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
E T Fossel
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Abstract

Our laboratory has developed nuclear magnetic resonance (NMR) techniques for detecting cancer. Using water-suppressed proton (H-1) NMR spectroscopy, we observed that the linewidths of the resonances of methyl and methylene moieties in lipoprotein lipids were consistently narrower in plasma samples from cancer patients than in those from controls. These findings have been corroborated by a number of independent laboratories, but other investigators have been unable to reproduce our results. One reason for the variability of results obtained with H-1 NMR may be that hypertriglyceridemia also induces linewidth narrowing of lipoprotein lipid methyl and methylene resonances, and can cause false positive results. We show that this ambiguity can be circumvented by using a second test based on the carbon-13 (C-13) NMR spectrum of plasma. Here we postulate that the cancer-associated changes seen in H-1 and C-13 NMR spectra are caused by peroxidation of lipoprotein lipids, an effect that may be induced by tumor necrosis factor-alpha released during malignancy.

核磁共振血液检测癌症:现状。
我们的实验室开发了核磁共振(NMR)技术来检测癌症。利用水抑制质子(H-1)核磁共振波谱,我们观察到癌症患者血浆样品中脂蛋白脂中甲基和亚甲基部分的共振线宽始终比对照组窄。这些发现已得到一些独立实验室的证实,但其他研究人员无法重现我们的结果。H-1 NMR结果变化的一个原因可能是高甘油三酯血症也会导致脂蛋白脂质甲基和亚甲基共振的线宽变窄,并可能导致假阳性结果。我们表明,这种模糊性可以通过使用基于等离子体碳-13 (C-13)核磁共振谱的第二种测试来规避。在这里,我们假设在H-1和C-13核磁共振光谱中看到的癌症相关变化是由脂蛋白脂的过氧化引起的,这种作用可能是由恶性肿瘤期间释放的肿瘤坏死因子α诱导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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