Potential protective effect of basil leaves extract against zinc oxide nanoparticle-induced nephrotoxicity in rats

Abstract

: Nanoparticles are compounds with special qualities that are very small in size (less than 100 nm). As a result, nanoparticles pose many different health concerns. Therefore, this study aimed to estimate basil leaf extract's protective effect on nephrotoxicity tempted by zinc oxide nanoparticles (ZnONPs) in male albino rats. Twenty-four male Sprague Dawley rats were divided into four groups. Group 1 rats were given a basal diet for 4 weeks and served as normal control. Group 2 rats were fed on a basal diet+ 500mg/ kg b.w. from leaves extract by gavage) for 4 weeks. Group 3 rats have a single dose of ZnONPs (600 mg/kg i.p.) on the 29 th day. Group 4 rats received a single dose of ZnONPs (600 mg/kg i.p.) on the 29 th day+ 500 mg/ kg b.w. leaf extract via gavage for 4 weeks. At the end of the experiment, blood samples were taken, internal organs were collected, weighted. A complete blood count was performed. Serum was separated to biochemical examination. Basil leaves extract recorded the highest catechein, benzoic, P-OH-benzoic, ellagic and gallic acids, respectively.