Oligosaccharides in human milk, achievements in analysis: a review

Alīna Beluško, L. Aumeistere, I. Ciproviča
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引用次数: 1

Abstract

Human milk oligosaccharides (HMOs) comprise about 20% of the total carbohydrates of human milk. There is currently a growing interest in HMOs as many researchers have recognized the importance of their benefits to infant health. Accumulated evidence suggests that HMOs are anti-adhesive antimicrobials that serve as soluble bait receptors, prevent pathogens from attaching to infant mucous membranes, and reduce the risk of viral, bacterial, and protozoan parasites. It also provides functionality including anti-adhesion and immunomodulators. Even though the composition of human milk in Latvia has been studied in detail, there are no studies on oligosaccharides in human milk. The aim of the study is to find out recent advances in the analysis of HMOs. Semi-systematic method was used to analyze the latest information about the recent advances in the analysis of HMOs by liquid phase separation methods, to investigate any known associations between HMOs composition and maternal nutrition and nutritional factors during lactation and the effect of HMOs on the infant’s development and health. The analysis of HMOs is considered very complex because of heterogeneity and different isomeric/anomeric structures of compounds. The proposed methods for analysing HMOs are largely based on liquid chromatography.
人乳中的低聚糖,分析成果综述
母乳低聚糖(HMOs)约占母乳总碳水化合物的20%。由于许多研究人员已经认识到hmo对婴儿健康的重要性,目前人们对hmo的兴趣越来越大。积累的证据表明,hmo是抗粘附抗菌剂,可作为可溶性诱饵受体,防止病原体附着在婴儿粘膜上,并降低病毒、细菌和原生动物寄生虫的风险。它还提供功能,包括抗粘连和免疫调节剂。尽管拉脱维亚人乳的成分已经被详细研究过,但还没有关于人乳中低聚糖的研究。这项研究的目的是找出hmo分析的最新进展。采用半系统的方法,对液相分离法分析HMOs的最新进展进行分析,探讨HMOs的组成与哺乳期母体营养及营养因子的关系,以及HMOs对婴儿发育和健康的影响。HMOs的分析被认为是非常复杂的,因为化合物具有异质性和不同的异构体/异构结构。提出的分析HMOs的方法主要基于液相色谱法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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