Hospitalizations among children with Sickle Cell Disease enrolled into the Kumasi SPARCo database

African Journal of Current Medical Research Pub Date : 2022-01-26 DOI:10.31191/afrijcmr.v5i1.90

Yaa Gyamfua Oppong–Mensah, S. Odoom, V. Paintsil, I. Nyanor, E. X. Amuzu, Suraj Abubakar Yawnumah, A. Mohammed, Emmanuel Asafo-Adjei, Paul Obeng, E. Dogbe, D. Ansong, A. Osei‐Akoto

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引用次数: 1

Abstract

BackgroundSickle cell disease (SCD) is the commonest monogenic haemolytic disorder in Africa. It continues to be a major public health burden. Newborn screening of SCD has been implemented in Kumasi, Ghana, since 1995 and SCD patients identified have been enrolled into the paediatric SCD clinic. The Sickle Pan African Research Consortium (SPARCo) which commenced in 2017 comprises of the Hub in Tanzania with two collaborating sites in Ghana and Nigeria has established a SCD patient consented database. Despite strides made in managing SCD, a significant proportion of patients are hospitalized from the various complications of the disease. This study set out to describe the main causes and outcomes of hospitalizations among paediatric patients with SCD at the Komfo Anokye Teaching Hospital (KATH) in Kumasi. MethodsProspectively, all patients in the database who were hospitalized over the 12-month period between April 2019 and March 2020 at the Paediatric Emergency Unit of KATH were followed up. Indications and outcomes of the hospitalizations were recorded. The data was exported to STATA/SE version 14.0 for analysis. ResultsA total of 201 hospitalizations were recorded over the period. Majority of the patients were males (57.2%, 95%CI: 50.1 - 64.2), in the age group 5-10 years (34.3%, 95%CI: 27.8 -41.3) and of phenotype SCD-SS (83.1%, 95%CI: 77.2 - 88.0). The common causes of hospitalization were VOPE (n=81, 40.3 %), ACS (n=52, 25.9 %), and infections (n=25, 12.4 %). Highest number of admissions was observed in November 2019 (n=34, 16.9 %) followed by June 2019 (n=25, 12.4 %). Six patients (3.0%, 95%CI: 1.1 - 6.4) died and the median (IQR) length of stay was 6 days (4-10). Comparing SCD-SS to SCD-SC, the case fatality was 2.5% and 0.5% respectively (p=0.985) ConclusionVaso-Occlusive Pain Events (VOPE), Acute Chest Syndrome (ACS) and infections were observed as the most common causes of hospitalizations among the SCD patients.

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在库马西SPARCo数据库中登记的镰状细胞病儿童的住院情况

背景镰状细胞病(SCD)是非洲最常见的单基因溶血疾病。它仍然是一个主要的公共卫生负担。自1995年以来，在加纳库马西实施了新生儿SCD筛查，发现的SCD患者已被登记到儿科SCD诊所。镰状泛非洲研究联盟(SPARCo)于2017年启动，由坦桑尼亚的中心和加纳和尼日利亚的两个合作站点组成，已经建立了一个SCD患者同意的数据库。尽管在处理SCD方面取得了长足的进步，但仍有很大一部分患者因该疾病的各种并发症而住院。本研究旨在描述库马西Komfo Anokye教学医院(KATH)儿科SCD患者住院的主要原因和结果。前瞻性地对数据库中2019年4月至2020年3月12个月期间在KATH儿科急诊科住院的所有患者进行随访。记录住院适应症和结果。数据导出到STATA/SE版本14.0进行分析。结果共记录201例住院病例。大多数患者为男性(57.2%，95%CI: 50.1 ~ 64.2)， 5 ~ 10岁年龄组(34.3%，95%CI: 27.8 ~ 41.3)， SCD-SS表型(83.1%，95%CI: 77.2 ~ 88.0)。常见的住院原因为VOPE (n=81, 40.3%)、ACS (n=52, 25.9%)和感染(n=25, 12.4%)。2019年11月的入学人数最多(n=34, 16.9%)，其次是2019年6月(n=25, 12.4%)。6例患者(3.0%，95%CI: 1.1 - 6.4)死亡，中位(IQR)住院时间为6天(4-10)。SCD- ss与SCD- sc的病死率分别为2.5%和0.5% (p=0.985)。结论血管闭塞性疼痛事件(VOPE)、急性胸综合征(ACS)和感染是SCD患者最常见的住院原因。

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African Journal of Current Medical Research

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