Extrapolation the effects of pyridoxine and isoniazid solutions from animals to human

Abstract

Previously, new data were obtained on the study of the properties of a 5% solution of pyridoxine hydrochloride in relation to the development of processes of complicated action of 10% solution of isoniazid for intravenous administration in a modular animal experiment. They allowed to reveal the presence of a pronounced protective action, which was attributed to the value of the indicator in the therapeutic and protective index. These toxicological studies indicate the possibility of developing a system of measures for the treatment and antidote effects of pyridoxine on the overdose of isoniazid, which is extremely important in the widespread use of drugs for the treatment of tuberculosis.