Adropin protein concentration level among obstructive sleep apnea patients – pilot study

Abstract

Introduction: Obstructive sleep apnea (OSA) is a chronic condition that is characterised by recurrent pauses in breathing during sleep. Adropin is a short peptide, mainly expressed in liver and brain. It plays a key role in energy homeostasis, lipid and glucose metabolism. Aim: To investigate the relationship between the adropin protein concertation in blood serum and severity of the disorder among OSA patients. Methods: 36 patients (83% male) referred to Sleep Disorders Centre were included in the study. Patients underwent polysomnography (PSG) examination. Peripheral blood was collected in the morning (6:00-7:00 am) after the PSG. Based on PSG results patients were divided into 2 groups: severe OSA (AHI>30) and control group (AHI Results: Higher adropin protein concentration level was observed in group with severe OSA (p=0.022) compared to controls. There has been difference between the groups regarding BMI (p Conclusion: Patients suffering from severe OSA have higher concentration level adropin than controls. There is a need to further investigate adropin, in larger cohort and in context of OSA comorbidities as it could be a relevant factor in their etiopathogenesis.