INVESTIGATING ACUTE ORAL TOXICITY OF YOUNG MANGO (Mangifera indica L.) LEAVES ON MICROLOGY OF LIVER AND KIDNEYS OF Mus muscular L.

Abstract

Histopathology is the most important issue in research pharmacy and clinical medicine. Microdiagnosis is a method of identifying and orienting treatment as well as disease prognosis. In testing acute toxicity, the youngleaves of mangoe extract (Mangifera indica L., MIL) was investigated based on analysis and comparison of liver/kidney microstructure of normal mice (Mus musculus L.) and mice that drank at high doses of MIL. The liver and kidney of laboratory mice were separated from groups of normal mice drinking distilled water (physiological control), normal mice drinking 1000 mg/kg, normal mice taking 2500 mg/kg and rats taking5000 mg/kg b.w., only one time. The observed results showed that the microstructure of the liver/kidney of rats drinking methanol extract MIL were damaged when compared to physiological control mice. This means that high doses of MIL have adverse effects on the liver/kidney of normal mice. From these results, it is concluded that MIL extract should not be taken arbitrarily not only in the body with any pathogenesis but also in the healthy body without the guidance of the pharmacist.