Automatic relevance source determination in human brain tumors using Bayesian NMF

Abstract

The clinical management of brain tumors is very sensitive; thus, their non-invasive characterization is often preferred. Non-negative Matrix Factorization techniques have been successfully applied in the context of neuro-oncology to extract the underlying source signals that explain different tissue tumor types, for which knowing the number of sources to calculate was always required. In the current study we estimate the number of relevant sources for a set of discrimination problems involving brain tumors and normal brain. For this, we propose to start by calculating a high number of sources using Bayesian NMF and automatically discarding the irrelevant ones during the iterative process of matrices decomposition, hence obtaining a reduced range of interpretable solutions. The real data used in this study come from a widely tested human brain tumor database. Simulated data that resembled the real data was also generated to validate the hypothesis against ground truth. The results obtained suggest that the proposed approach is able to provide a small range of meaningful solutions to the problem of source extraction in human brain tumors.