KARAKTERISTIK KLINIS DAN DERAJAT BERAT GEJALA MOTORIK PENYAKIT PARKINSON DI RSUP SANGLAH DAN RSUD WANGAYA DENPASAR

Pristanova Larasanti, Dewa Putu Gede Purwa Samatra, S. Trisnawati, I. K. Sumada
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Abstract

Background: Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The Global Burden Disease (GBD) report published in 2018 estimated there were 6.1 million individuals suffering from PD globally and causing 3.2 million Disability-Adjusted Life Years (DALY) and 211,296 deaths in 2016. Disability mainly caused by motor symptoms. This study aims to determine the clinical characteristics and motor severity in PD patients in Sanglah and Wangaya General Hospital Denpasar. Method: Descriptive observational study with cross-sectional design. Samples taken consecutively from all patients diagnosed with PD at Neurology Polyclinic in Sanglah and Wangaya General Hospital from December 2018 - February 2019. Result: From 47 subjects with PD, 72.3% were male, 83% had onset within 1-5 years, and the mean age was 63.87 ± 8.67 years. As many as 44.7% subjects had Hoehn-Yahr 2 stadium, with an average MDS-UPDRS III score of 35.11 ± 21.39, and 48.9% subjects had mild severity. As many as 59.6% subjects had the status of ON. Motor severity showed a trend that increases with increasing staging, but was not seen when compared to the onset. This result might be affected by the ON/OFF status during examination. Conclusion: Parkinson's disease in Sanglah and Wangaya General Hospital is more common in men and over the age of 50 years, and most are found in moderate severity. There is a trend of worsening motor severity with the increasing Hoehn-Yahr stadium. Examination using UPDRS-III is recommended to be done both on ON and OFF state to get more sensitive results
RSUP ssup和WANGAYA诊断中的帕金森运动症状的临床特征和严重程度
背景:帕金森病(PD)是第二常见的神经退行性疾病。2018年发布的全球负担性疾病(GBD)报告估计,2016年全球有610万人患有PD,造成320万个残疾调整生命年(DALY)和211296人死亡。残疾主要由运动症状引起。本研究旨在了解登巴萨Sanglah和Wangaya总医院PD患者的临床特征和运动严重程度。方法:采用横断面设计的描述性观察研究。从2018年12月至2019年2月在Sanglah和Wangaya综合医院的神经病学综合诊所连续采集了所有诊断为PD的患者的样本。结果:47例PD患者中,男性占72.3%,1 ~ 5年内发病83%,平均年龄63.87±8.67岁。多达44.7%的受试者患有Hoehn-Yahr 2型体育场,MDS-UPDRS III平均评分为35.11±21.39,48.9%的受试者患有轻度严重程度。有59.6%的受试者处于ON状态。运动严重程度随分期的增加而增加,但与发病相比没有观察到。此结果可能会受到检查时ON/OFF状态的影响。结论:Sanglah and Wangaya总医院帕金森病多见于男性和50岁以上人群,且多为中度。随着Hoehn-Yahr体育场的增加,运动严重程度有恶化的趋势。建议使用UPDRS-III进行on和OFF状态检查,以获得更敏感的结果
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