Topological effects of charge transfer in telomere G-quadruplex: Mechanism on telomerase activation and inhibition

Xin Wang, Shiming Liang
{"title":"Topological effects of charge transfer in telomere G-quadruplex: Mechanism on telomerase activation and inhibition","authors":"Xin Wang, Shiming Liang","doi":"10.1142/S021797921350001X","DOIUrl":null,"url":null,"abstract":"We explore charge transfer in the telomere G-Quadruplex (TG4) DNA theoretically by the nonequilibrium Green's function method, and reveal the topological effect of charge transport in TG4 DNA. The consecutive TG4(CTG4) is semiconducting with 0.2 ~ 0.3eV energy gap. Charges transfers favorably in the consecutive TG4, but are trapped in the non-consecutive TG4 (NCTG4). The global conductance is inversely proportional to the local conductance for NCTG4. The topological structure transition from NCTG4 to CTG4 induces abruptly ~ 3nA charge current, which provide a microscopic clue to understand the telomerase activated or inhibited by TG4. Our findings reveal the fundamental property of charge transfer in TG4 and its relationship with the topological structure of TG4.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv: Biological Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/S021797921350001X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

We explore charge transfer in the telomere G-Quadruplex (TG4) DNA theoretically by the nonequilibrium Green's function method, and reveal the topological effect of charge transport in TG4 DNA. The consecutive TG4(CTG4) is semiconducting with 0.2 ~ 0.3eV energy gap. Charges transfers favorably in the consecutive TG4, but are trapped in the non-consecutive TG4 (NCTG4). The global conductance is inversely proportional to the local conductance for NCTG4. The topological structure transition from NCTG4 to CTG4 induces abruptly ~ 3nA charge current, which provide a microscopic clue to understand the telomerase activated or inhibited by TG4. Our findings reveal the fundamental property of charge transfer in TG4 and its relationship with the topological structure of TG4.
端粒g -四重体电荷转移的拓扑效应:端粒酶激活和抑制的机制
利用非平衡格林函数方法从理论上探讨了端粒g -四重体(TG4) DNA中的电荷转移,揭示了TG4 DNA中电荷转移的拓扑效应。连续的TG4(CTG4)具有半导体性质,能隙为0.2 ~ 0.3eV。电荷在连续TG4中传输有利,但在非连续TG4 (NCTG4)中被捕获。NCTG4的全局电导与局部电导成反比。从NCTG4到CTG4的拓扑结构转变引起了~ 3nA电荷电流的突变,这为了解TG4激活或抑制端粒酶提供了一个微观线索。我们的发现揭示了TG4中电荷转移的基本性质及其与TG4拓扑结构的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信