Evaluatıon of kallistatin and some biochemical parameters in rats with experimental Liver Injury

Ehsan SEPEHRİZADEH1, Süleyman Kozat, Ö. F. Keleş, Erhan Ayna
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Abstract

This study aims to determine the possible relationship between the levels of Kallistatin and the severity of liver injury in rats that were exposed to carbon tetrachloride (CCl4). According to the results, serum ALT, AST, LDH, GGT and Collagen-I and Collagen-III levels in rats in the severe group were higher than control. Histopathological examination of rats in injury groups showed severe morphological changes that were resulted in cell dissociation and disruption of the liver lobe architecture in the liver parenchyma of rats that received CCl4. Kallistatin serum level decreasing respectively in M1, M2, and S groups compared to the control group, and the lowest amount was belonging to the severe group. As a result, there was a reverse connection between Kallistatin serum level and the liver injury intensity. Serum kallistatin levels are an essential parameter in determining liver tissue damage levels, and measuring it may help provide a treatment prognosis.
Evaluatıon卡利司他汀对实验性肝损伤大鼠的影响及生化指标
本研究旨在确定暴露于四氯化碳(CCl4)的大鼠的卡利司他汀水平与肝损伤严重程度之间的可能关系。结果显示,重症组大鼠血清ALT、AST、LDH、GGT及胶原- i、胶原- iii水平均高于对照组。损伤组大鼠的组织病理学检查显示,CCl4对肝实质造成严重的形态学改变,导致细胞解离和肝叶结构破坏。与对照组相比,M1、M2、S组血清卡利司他汀水平分别下降,重症组最低。结果表明,血清卡利司他汀水平与肝损伤强度呈负相关。血清卡利司他汀水平是确定肝组织损伤水平的重要参数,测量它可能有助于提供治疗预后。
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